p16 and Ki-67 immunohistochemical staining reduces inter- and intra-observer variability in the grading of cervical squamous intraepithelial lesions of South African women

Abstract

Background: Cervical carcinoma was the second leading malignancy in South African women (following breast carcinoma) in 2010. This study aimed to correlate histopathological criteria and immunohistochemical stains in terms of the grading of cervical intraepithelial precursor lesions and evaluate intra- and inter-observer variability with only histology and with additional immunohistochemical stains.