Pansinusitis in an HIV-infected patient due to Scedosporium apiospermum (Pseudallescheria boydii complex)

Abstract

Pseudallescheria boydii is a very rare cause of sinusitis but an increasingly recognised infection among HIV-infected patients. Its correct identifcation is vital as voriconazole, which has good in vitro activity against the fungus, has important interactions with antiretroviral drugs. We report the successful treatment of Scedosporium apiospermum pansinusitis, in an HIV-infected woman, which required alteration of antiretroviral therapy.